In 2014, two seminal papers described a subset of patients with aquaporin-4 (AQP4)-Ab-seronegative neuromyelitis optica spectrum disorder (NMOSD) who harboured MOG-Abs, detected using the newer assays. The significance of these antibodies became clearer in the 2010s, when newer, more specific assays became available that allowed for the detection of the biologically relevant MOG-Abs 2. However, they were also detected in other central nervous system (CNS) conditions such as isolated optic neuritis or myelitis, acute disseminated encephalomyelitis, and cortical encephalitis 1. Antibodies against MOG (MOG-Abs) were first identified in patients with multiple sclerosis (MS) in the early 1990s and were then thought to be biomarkers of MS 1. Any medication started would be discussed in full detail if needed.Myelin oligodendrocyte glycoprotein (MOG) is expressed on the surface of myelin sheaths and oligodendrocyte membranes, and is involved in oligodendrocyte microtubule stability, cellular adhesion and the complement cascade 1. These types of medicine are used to control your child’s immune system and to damp down inflammation. Medicines that may be used include azathioprine, mycophenolate mofetil or in some cases rituximab. If a child continues to have relapses, then maintenance treatment may be required to prevent further relapses. Both these treatments will be explained in full detail if needed.įor many children, after an initial attack, it can be difficult to predict if further attacks will happen so it is not always beneficial to start a long term treatment. In rare cases, if high dose steroids do not improve your child’s symptoms, other treatment may need to be considered, such as intravenous immunoglobulins (IVIGs) or plasma exchange. Steroids do not change your child’s risk of a relapse. Steroids have both short and long term side effects so your child will not usually stay on them for a long time. These side effects will be discussed with you in more detail at the time. Your child may then start an oral course of steroid tablets and you will be given a plan of how to reduce these gradually.Ĭhildren usually respond very well to steroid treatment during this acute phase. This will usually be given at high dose for three to five days via a cannula into a vein. Intravenous steroid treatment is often used to treat the acute symptoms of demyelination to try to reduce the inflammation that has occurred. How is MOG antibody demyelination diagnosed? These relapses could happen either months or even years apart and therefore it can be difficult to predict. arm weakness (if higher up the spinal cord)Ĭhildren may also have symptoms such as nausea, vomiting, ataxia (unsteadiness) and extreme lethargy or tiredness.įor many children that have a MOG antibody demyelination episode, it will be a one off and they have no further attack of symptoms (relapse). However, some children may be at risk of further relapses.Symptoms come on quickly and can vary depending on where the inflammation has occurred in the spine. Transverse myelitis is inflammation of the spinal cord. Optic neuritis is demyelination of the optic nerve and can affect one or both eyes. Some children may initially present with acute disseminated encephalomyelitis (ADEM) which is an inflammatory condition that mainly affects the brain and others may have signs of optic neuritis or transverse myelitis. Symptoms of MOG antibody demyelination can be variable from person to person and can range from mild to severe depending on which parts of the brain are affected.
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WARNING: GPT (GUID Partition Table) detected on '/dev/sdb'! The util fdisk doesn't support GPT. I/O size (minimum/optimal): 512 bytes / 512 bytes Sector size (logical/physical): 512 bytes / 512 bytes It finished installing Ubuntu, but now when i start my machine it just takes me to the grub rescue prompt. Update: I went ahead and said yes, it can unmount those partitions. Why is this not working? What am I supposed to do? Would you like the installer to try to unmount these partitions again? Please close any applications using these mount points. media/ubuntu/Three\ Terabyte Drive Terabyte\ DriveDrive The installer needs to commit changes to partition tables, but cannot do so because the partitions on the following mount points could not be unmounted: A few minutes passed when this popup appeared: Failed to unmount partitions I chose to install ubuntu alongside windows 7, and hit continue. I wonder, if I had said yes above, would I have lost all the data on those drives? I said no because I don't want to lose my windows 7 installation, nor any of that data. I started Ubuntu in "Try Ubuntu" mode and then opened gparted, and then deleted the unused partition for the last third of my drive, then tried to install ubuntu.ĭuring the install, it asked me if I wanted to unmount the drives I already have The installer has detected that the following disks have mounted partitions:ĭo you want the installer to try to unmount the partitions on these disks before continuing? If you leave them mounted, you will not be able to create, delete, or resize partitions on these disks, but you may be able to install to existing partitions there. I have a 3TB drive that has one 2TB partition on it, so the last 1TB is completely unused, which is where I want to install ubuntu. I have windows 7 installed already and want to keep that installation. I'm trying to install Ubuntu from a pen drive. Safer just to hire actors.) And some comedians such as the Jerky Boys and guests on the former Comedy Central show Crank Yankers have relied on the prank call for laughs.īut generally it seems as kids grow up, the needs these prank calls served tend to dissipate, and they leave the jokes behind for the next generation of puberty-flustered youngsters to discover. (Even a fairly silly one-a contest promising “100 Grand” that ended with the winner receiving the candy bar instead of cash-ended in a lawsuit accusing the radio station of deception. Although it seems most such calls may be faked these days for legal reasons. I’m thinking mostly of morning show radio hosts whose pranks are often curdled into meanness-trying to catch people in the act of cheating, and the like. This is not to say adults never prank call. The boys were ultimately fired-this is partly why women ended up working as telephone operators in a time before it was common for them to work outside the home. Bell's chief engineer ended up referring to the boys as "Wild Indians." They purposely crossed lines so that strangers would suddenly find themselves talking to each other. The boys disconnected calls as they were still taking place. They also regularly played practical jokes on those customers. And they did, but as my colleague Megan Garber wrote in 2014: When Bell Telephone first started back in 1878, the company hired teen boys to be its operators, thinking they’d make for cheap, energetic labor. In fact, in the early days of the phone, the pranksters sometimes were telephone-company employees. This is probably particularly satisfying for kids, who usually carry out adults’ demands. “In executing the prank, he is able to assume a position of authority … make demands … and have the majority of these demands carried out,” Harris writes. Then the prankster calls over and over again in the next 15 minutes, “and if they answer let go a blood curdling scream.” “Telephone pranks serve as a means of releasing hostility and frustration with a minimum risk of retaliation.” In one variation, the caller warns them not to answer the phone for 15 minutes “because if they do, the telephone repairman will receive a fatal shock,” as one survey respondent told Harris. In another common genre of phone prank, the caller pretends to be from the telephone company and tries to get the answerer to do something, like blow in the phone to “fix” it. “Pranksters become aware of the power of words in unusual or different contexts.” “There is also a certain amount of linguistic delight in discovery,” Harris writes. “Do you have pop?” “Yes.” “Send him home Mom wants him.” Perhaps the most well-known is the “catch question,” à la “Is your refrigerator running?” A few others: There are several classic forms this can take. “Telephone pranks serve … as a means of releasing hostility and frustration with a minimum risk of retaliation,” Dresser writes. The calls are almost always made in groups, her survey found, so there’s a bonding element, and “the caller becomes the center of attention among his peers.”ĭresser, Jorgensen, and Harris all note that a prank call also serves as a sort of low-stakes rebellion, a chance to embarrass the adults that usually have power over them. In her 1973 paper “Telephone Pranks ,” the folklorist Norine Dresser writes that the pranks “serve several social needs” for kids that age. The few studies on prank calls that exist estimate that the pastime is most popular among kids from ages 11 to 14 or 15. In each case the denouement was highly farcical, and the reputed corpses are now hunting in a lively manner for that telephonistįrom then to now, most people have tended to make prank calls during a brief window of adolescence. A Grave Joke on Undertakers.-Some malicious wag at Providence, R.I., has been playing a grave practical joke on the undertakers there, by summoning them over the telephone to bring freezers, candlesticks and coffins for persons alleged to be dead. Tap Continue when you see a prompt to upgrade account security. Answer your security questions, then tap Continue. On the web: Go to and sign in with your Apple ID.Next to Two-Factor Authentication, click Turn On and follow the onscreen instructions. On your Mac: Choose Apple menu > System Settings, then click your name.Then tap Continue and follow the onscreen instructions. On your iPhone or iPad: Go to Settings >, then tap Sign-In & Security.If you're not using two-factor authentication for your Apple ID, you can turn it on right on your device or on the web: Learn where two-factor authentication is available. Two-factor authentication requires iOS 9 or later, OS X El Capitan or later, or iCloud for Windows 5 or later. We recommend that you use two-factor authentication and protect your device with a passcode (or login password on Mac) and Face ID or Touch ID, if your device supports it. Certain Apple services and features, such as Apple Pay and Sign in with Apple, require two-factor authentication. Two-factor authentication is the default security method for most Apple IDs. Because just knowing your password isn't enough to access your account, two-factor authentication dramatically improves the security of your Apple ID and the data that you store with Apple. When you sign in with your Apple ID for the first time on a new device or on the web, you need both your password and the six-digit verification code that's automatically displayed on your trusted devices. Two-factor authentication is an extra layer of security for your Apple ID, designed to make sure that you're the only one who can access your account-even if someone else knows your password. Like the Template component we built earlier, ESP templates are meant to serve as the shell for our email. Typically, you can either pick from a pre-designed template, or build your own in HTML. These tools are typically built for non-developers, and they have their own template system. I personally use ConvertKit, but there are plenty of options, like Mailchimp, ActiveCampaign, etc. It turns out, sending email is its own Hard Problem, and most people outsource that work to an ESP-“Email Service Provider”. Link to this headingIntegrating with Email Service ProvidersĪlright, so we've generated a beautiful HTML email. Once you know where your emails will live, we can update our Template component to receive an id prop: In retrospect, I don't recommend trying to do it this way □. In my case, I decided instead to pre-generate individual pages for each email, using getStaticPaths and getStaticProps. If you're also using Next.js, you can check out this GitHub discussion that shares some potential solutions. I wasn't able to load the emails using fs.readFileSync in production. In practice, I ran into some trouble with this approach. Our API endpoint can generate the full HTML we need, so in theory, we can add a link to this API endpoint in the template, and we're done. The good news is that we already have most of the code we'll need. For example, maybe someone wants to share the newsletter in a company Slack or Discord. I've also heard from several people who appreciate “View on web” links for other reasons. This is a handy thing to include as a fallback, in case the HTML email doesn't render correctly. It's common for newsletters to include a “View on web” link, which will load the current email in the browser. Link to this headingThe “View on Web” link I recently learned about heml, and it looks super compelling! Overall, I think MJML does deliver on its promises, though it's not perfect. Unfortunately, I don't know very much about the email accessibility space, but this is something I plan on investigating in the future. Because headings and paragraphs use the same tag, I imagine screen readers struggle a bit with the content. I'm also a bit concerned about the accessibility implications. It won't help us at all if we dump a bunch of custom HTML inside an tag! Of course, MJML can only help us if we follow its conventions. I definitely got more complaints about my hand-crafted HTML emails. Amazingly, I only heard from 2 or 3 people who experienced minor rendering issues. I sent an email generated with MJML to about 30,000 people, asking them to let me know if anything looked busted. Examining the compiled output, it certainly seems to be adding in a ton of stuff, presumably to address various quirks! The core promise of MJML is that it produces responsive, client-friendly HTML. It takes a while to figure out exactly how all of these pieces fit together, and how to combine them for optimal results.įor more information, and to learn about all of the building blocks included, be sure to check out the official MJML documentation. That said, there's definitely a bit of a learning curve. But for most of us, who just want to build a professional responsive email template, I think it's a fabulous tool. It's definitely nowhere near as powerful as modern CSS, and if you have a really ambitious layout, it might not be powerful enough. With these basic building blocks, it's possible to build most typical email layouts. For example, you can add social sharing links with, or expandable text chunks similar to details/summary with. You're granted the full flexibility of HTML, but without its guardrails, you're no longer guaranteed to have a consistent, universal experience across all email clients.įinally, there are some handy pre-built utilities you can use. MJML won't process anything inside an tag. You can create headings by applying cosmetic styles as inline attributes, like: It doesn't exactly map onto an tag - for example, we can add an href attribute, and it'll wrap that image in an anchor tag, linking to the provided URL.Ĭuriously, all text elements (paragraphs and headings) use the same tag. There are a ton of MJML tags for various things, like, which renders a stretchy responsive image. This is the fundamental thing that makes MJML emails “responsive”. On smaller screens, though, the columns stack vertically. On a large screen, columns will sit side-by-side, as if in a Flex row. Each section is meant to be a distinct visual chunk of the email.Įach section should have one or more columns, using. The MJML language provides a set of common tags you can use to structure your email.Įach email is a collection of sections, using the tag. 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Financing Your Car Through Sandy Sansing Automotive Other General Hospital spoilers later next week say that Liz will share what she knows with Franco, but also that Drew and Elizabeth will be stunned! So General Hospital viewers know he will wake up but will he be Franco, or will he be Drew? Time will tell! General Hospital viewers can all agree that being kidnapped, and then possibly rendered unconscious to wake up to possibly be hooked up to hospital-type machines in a motel room would be horrifying! General Hospital Spoilers – Franco Baldwin Will Be Asleep, But He Will Wake Up According To Other GH Spoilers Other General Hospital spoilers say that Francowill be horrified it is a good bet that he will be horrified if he is indeed forced to “take that drive” in the form of Drew’s memories being implanted into his brain by who he will consider being a mad scientist! GH Spoilers – Franco Baldwin Is Horrified General Hospital viewers already know that Sonny Corinthos (Maurice Benard) will be called for help as well. Other General Hospital spoilers tease that Shiloh will either kidnap Franco outright or he will be kidnapped to put Drew’s memories in while trying to help rescue Jason and Sam McCall (Kelly Monaco), possibly with Drew and maybe Curtis Ashford (Donnell Turner). Robin Scorpio-Drake (Kimberly McCullough) discovered him in the Swiss Clinic where she was kidnapped to resurrect Stavros Cassadine (Robert Kelker-Kelly) and thought he was Jason. When Kevin was contacted about his brother and his terrible mental issues, it’s entirely possible that those came from the memory transfer also, and Jason didn’t receive Drew’s memories, and Drew was near death when Dr. General Hospital Recap Monday August 5: Shiloh Kidnaps Sam, Brad And Obrecht Argue /fUt5wkRssN Kevin Collins (Jon Lindstrom) and Ryan Chamberlain (Jon Lindstrom), who was in the DVX at that time, left evidence of Kevin’s receipt of Ryan’s memories, according to historical GH recaps from the mid- 1990s when he thought he was Ryan. The second study, which was also performed by Cabot on Dr. Cabot himself more than likely performed, resulted in cross-transferred memories in Anna Devane (Finola Hughes) and her twin Alexandra Marick (Finola Hughes). Jason is the only twin in the studies who did not receive cross-transferred memories from his twin the first study, which Dr. The phrase “Don’t take that drive” could indicate either driving in a car, or it could also mean a flash drive one puts in a device or a computer! General Hospital viewers now know that the flash drive containing Drew Cain’s (Billy Miller) memories were stolen, by someone that Shiloh Archer (Coby Ryan McLaughlin) contacted, so obviously.However, there is a way that the two different ways of taking each of these warnings could all work together! General Hospital Spoilers – Elizabeth Webber Gets An Alarming Phone CallĮlizabeth’s call will most likely involve finding out that Franco has been Dr. There may be two different meanings to each of these two warnings: the phrase “not feeling himself” could indicate either physically not being able to feel himself, or mentally not feeling himself. General Hospital Star Donna Mills Lands A New Gig View Story GH Spoilers – There May Be Two Different Meanings To Each Of These Two Warnings |
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